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Wednesday, April 2, 2025

The science of longevity: how the elite are hacking ageing

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Ageing has always been a source of fear and fascination.

From the alchemists of ancient times to the ultra-wealthy tech entrepreneurs of today, humanity has long sought the secrets to eternal youth.

The latest chapter in this saga unfolds at gatherings like the Don’t Die Summit, where billionaires, biohackers, and scientists unite to outwit biological clocks and hack longevity.  

The summit’s name may sound like a sci-fi convention, but its purpose is deeply rooted in the real-world ambitions of the elite: to live longer, healthier, and perhaps even indefinitely.  

What is biohacking?

Biohacking, a term that encompasses everything from intermittent fasting to cutting-edge genetic engineering, is at the heart of the longevity movement. 

For some, it’s as simple as taking supplements or following a strict diet.

For others, it involves costly and experimental treatments like plasma transfusions, where younger blood is infused into an older recipient in hopes of rejuvenating the body.   

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Bryan Johnson, a tech entrepreneur, made headlines when he revealed that he had undergone such a procedure using his son’s plasma. 

Peter Diamandis, founder of the XPRIZE Foundation, is another vocal advocate of biohacking, undergoing plasma exchanges as part of his ambitious health regimen.

These practices, while controversial, showcase the lengths to which the wealthy are willing to go in their pursuit of longevity.  

For many of these individuals, biohacking isn’t just about extending life, it’s about optimising every aspect of their health. 

Reinhard Reichmuth, another prominent figure in the movement, practices intermittent fasting, follows a plant-based diet, and invests millions into longevity research.

His personal goal? To live to 120 in peak physical condition.  

As scientific innovations continue to emerge, alive with the potential to reshape human life itself, society must grapple with the implications of this age-defying pursuit.

The science behind longevity

The science of ageing is advancing rapidly. Researchers have identified several groundbreaking treatments that could one day extend human lifespans significantly.  

  • Rapamycin: Originally developed to suppress immune responses in organ transplant patients, this drug has been shown to extend the lifespans of mice by up to 25%. 
  • Senolytics: These treatments aim to clear out senescent old, damaged cells that accumulate in the body, and contribute to ageing.
  • Teenage blood plasma: In one of the more controversial experiments, scientists found that injecting old mice with the plasma of young humans appeared to rejuvenate the animals.  

These treatments don’t just delay death in lab animals, they also improve their quality of life by reducing age-related diseases. 

“The idea is that ageing biology is this lever that allows us to dial back on multiple diseases,” says Borch Jensen, a scientist whose company focuses on treatments for diseases of ageing.  

However, these advancements raise ethical and societal questions, particularly around access, and equity.    

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The three types of biohacking

Nutrigenomics: hacking your diet and environment  

Nutrigenomics is the study of how food, exercise, and environmental factors affect your body.

This form of biohacking focuses on using nutrition and lifestyle changes to improve how your body functions.

For example, adjusting your diet, managing stress, improving sleep, and even tweaking your exposure to light and sound are all part of nutrigenomics.

Think of it as learning how your body responds to different inputs like food or exercise, and using that knowledge to live better.  

Your body is constantly changing, and the food you eat, the quality of your sleep, and even your stress levels can influence your health.

Nutrigenomics teaches you to work with these changes by making informed choices.  

DIY biology (DIYbio)

DIY biology is a movement where everyday people experiment with biology and life sciences outside traditional labs. I

t’s like citizen science for biohackers. 

Many DIYbio enthusiasts learn from scientists and educators who teach them how to conduct experiments at home.  

While this form of biohacking is fascinating, it’s also controversial.

Because much of the research is experimental and lacks strict oversight, critics argue that DIYbio can be risky.

It celebrates curiosity and innovation.

While it’s not for everyone, it’s a reminder that science isn’t just for professionals it’s for anyone willing to learn.  

Grinder biohacking: technology meets the human body  

Grinder biohacking takes things to the extreme by merging technology with the body.

This involves implants, body modifications, or chemical enhancements to “upgrade” human capabilities.  

For example, grinders might implant RFID chips under their skin to unlock doors or experiment with supplements to push their bodies to new limits.

However, these techniques are often experimental and carry significant risks.  

While grinder biohacking is not for the faint of heart, it highlights the lengths some biohackers will go to explore the boundaries of human potential.  

For some, biohacking translates to straightforward changes like taking dietary supplements or adhering to a strict fitness regime.

How to start biohacking your life

Biohacking isn’t just for tech enthusiasts or scientists, it’s for anyone looking to improve their health and well-being.

Here are some simple, beginner-friendly ways to get started. 

Try an elimination diet

Do you suffer from fatigue, skin issues, or digestive problems? An elimination diet can help you identify which foods might be causing your symptoms.

This short-term eating plan involves cutting out common allergens (like dairy or gluten), and slowly reintroducing them to see how your body reacts.

Food plays a huge role in how your body feels and functions. By understanding what works for you, you can optimise your diet and feel better.  

Cut out added sugar

Sugar is one of the most addictive substances in modern diets.

Cutting back on added sugars (like those in sodas and processed snacks) can improve your energy levels, mood, and overall health.  

Naturally occurring sugars in fruits and dairy are fine focus on eliminating processed and artificial sweeteners.  

Experiment with intermittent fasting

Changing when you eat can be just as powerful as changing what you eat.

Intermittent fasting where you cycle between eating and fasting periods has gained popularity for its ability to regulate blood sugar, improve metabolism, and even support weight loss.  

Fasting helps your body reset and can improve hormone regulation, including ghrelin (your hunger hormone) and leptin (your fullness hormone).  

Sleep smarter

Sleep is one of the most underrated health hacks.

Lack of sleep can lead to a weakened immune system, increased appetite, and a higher risk of chronic diseases.

Aim for 7-9 hours of quality sleep each night.  

Fuel your body with healthy fats

The ketogenic (keto) diet focuses on eating healthy fats to get your body into a state of ketosis, where it burns fat for energy instead of carbs.

While keto isn’t for everyone, increasing your intake of healthy fats (like avocado, nuts, and olive oil) can support brain health and energy levels.  

Fats are essential for hormone production, brain function, and overall health. 

Meditate to reset your mind

Biohacking isn’t just about the body, it’s also about the mind.

Meditation is one of the best ways to improve mental clarity, reduce stress, and boost productivity.  

Regular meditation has been shown to lower inflammation, improve sleep, and even rewire the brain for greater focus.  

Is biohacking right for you?

Biohacking is about taking small, intentional steps to improve your health.

Whether it’s trying a new diet, sleeping better, or meditating, anyone can start biohacking today.

However, it’s important to approach biohacking with caution.

While many techniques are safe and supported by science, others like grinder biohacking are experimental and risky.

Always do your research and consult with a healthcare professional before making major changes to your routine.  

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