Ghana will face a repeat of the 2010 World Cup quarter-final after being drawn with Uruguay in the group stages of the 2022 tournament.
The Black Stars were eliminated by the two-time winners on penalties in South Africa, having seen Asamoah Gyan miss an extra-time spot-kick after Luis Suarez was sent off for handball.
Ghana FA president Kurt Okraku told BBC Sport Africa: “It is clear it will be revenge time”.
Meanwhile, Tunisia were paired with defending champions France and Cameroon were put into the same group as five-time winners Brazil.
Africa Cup of Nations holders Senegal will take on hosts Qatar and Morocco are in the same group as Belgium, who are second in the world rankings.
The Fifa World Cup takes place between 21 November and 18 December.
Only three sides from the continent have ever progressed to the quarter-finals; Cameroon in 1990, Senegal in 2002 and Ghana in 2010.
Below, BBC Sport Africa analyses how the five African sides fared in Friday’s draw.
Senegal have been Africa’s top-ranked side for the past three years and won the Nations Cup for the first time in January.
The Teranga Lions are in Group A, and will face three-time runners-up the Netherlands in their first game before clashes against Qatar and Ecuador.
Morocco will open up against 2018 runners-up Croatia in Group F and have also been drawn with Belgium and Canada, who have qualified for the first time since 1986.
Tunisia have been drawn with defending champions France in Group D.
The Carthage Eagles will start their campaign against Denmark, and will also face the winner of an intercontinental play-off – which will be either Peru, Australia or the United Arab Emirates.
Cameroon, who are in Group G, have met Brazil twice in previous tournaments, losing 3-0 to the South Americans in 1994 and 4-1 in 2014.
The Indomitable Lions, have qualified for an African record-extending eighth World Cup finals, have also been drawn with Serbia and Switzerland, who they will face first.
Ghana, returning to the tournament after missing out on Russia 2018, take on Portugal in their first game in Group H.
The Black Stars, who at 60th in the world could be the lowest-ranked nation at the tournament, have also been paired with South Korea as well as the Uruguayans.
