One enforced change will certainly see Christian Eriksen drop out of the starting lineup, with the midfielder facing a sizeable spell out of action.
The Danish midfielder left Old Trafford on crutches after picking up an ankle injury in the weekend win over Reading and could now miss up to four months.
Thankfully for United, they hold a 3-0 advantage in the tie after a confident dislay at the City Ground last week.
That factor is likely to play a key role in Ten Hag’s selection, with Diogo Dalot, Axel Tuanzebe, Donny van de Beek and Anthony Martial all expected to miss out through injury.
Luke Shaw has missed the last two games through illness while Scott McTominay was also absent on the weekend.
United went with their reserve centre-back pairing and first-choice frontline against Reading so, given the aggregate scoreline, it is plausible that the reverse could happen for this game.
However, Ten Hag has taken the cup competitions very seriously in his club’s pursuit of a first trophy in over five years, and he may opt to take no chances for the visit of Forest.
Predicted Manchester United XI: Heaton; Wan-Bissaka, Varane, Martinez, Shaw; McTominay, Fred; Elanga, Fernandes, Garnacho; Weghorst.
