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Tuesday, April 22, 2025

NFL playoff odds, lines, point spreads: Updated divisional round betting info for picking every game

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Following an entertaining super wild-card weekend, the NFL playoffs continue with the divisional round, and betting odds are already posted for the next slate of games. Once the winner of Monday night’s Buccaneers/Cowboys contest is decided, the odds board will be complete, but for now, we have odds for three of the four matchups. As we do at the start of each week, we’ll list every divisional round game’s spread, moneyline, and total, updating those numbers as they get bet throughout the next few days.

The divisional round slate kicks off on Saturday afternoon as the top-seeded Kansas City Chiefs (-8.5) host the fourth-seeded Jacksonville Jaguars for the second time this season in Arrowhead Stadium (4:30 p.m. ET, NBC). Later that day, the NFC’s top seed, the Philadelphia Eagles (-7) host the sixth-seeded New York Giants in an NFC East-centric battle in prime time (8:15 p.m. ET, FOX). The action then spills over into Sunday as the second-seeded Buffalo Bills (-4) face off against the third-seeded Cincinnati Bengals (3:00 p.m. ET, CBS) and concludes with the San Francisco 49ers playing host to the winner of Monday night’s Buccaneers/Cowboys matchup (6:30 p.m. ET, FOX).

Keep in mind these lines will move throughout the week as we get updates on the playing status of key starters and betting limits increase. Below, we take a look at the latest odds for the divisional round from BetMGM and offer up an early bet to consider.

NFL divisional round playoff odds

Odds courtesy of BetMGM

Game Spread
Kansas City Chiefs vs. Jacksonville Jaguars KC -8.5 (-110)
Philadelphia Eagles vs. New York Giants PHI -7 (-115)
Buffalo Bills vs. Cincinnati Bengals BUF -4 (-110)
San Francisco 49ers vs. TBD OTB

NFL wild-card playoff moneylines

Game Moneyline
Kansas City Chiefs vs. Jacksonville Jaguars KC -450 | JAX +333
Philadelphia Eagles vs. New York Giants PHI -300 | NYG +240
Buffalo Bills vs. Cincinnati Bengals BUF -200 | CIN +165
San Francisco 49ers vs. TBD OTB

NFL wild-card playoff over/unders

Game Over/Under
Kansas City Chiefs vs. Jacksonville Jaguars 51.5
Philadelphia Eagles vs. New York Giants 48
Buffalo Bills vs. Cincinnati Bengals 50.5
San Francisco 49ers vs. TBD OTB

NFL divisional round playoff best bet

*Odds and analysis as of Monday 1/16*

Bills -4 (-110) vs. Bengals

While both Buffalo and Cincinnati’s wild-card games didn’t go as smoothly as they’d hoped for, they still managed to survive and advance. At this juncture of the season, it’s not about playing perfect football, it’s about executing when it matters most. Buffalo certainly had its fair share of miscues in its narrow 34-31 victory over the Dolphins, but we’ll still back them to notch a home win and cover over Cincinnati. For the most part, Buffalo’s offense still did its part, putting up 423 yards of total offense on 5.9 yards per play, but untimely turnovers threw a wrench in its plans for a stress-free victory. Cincinnati’s offense, on the other hand, had some issues, putting up only 234 yards on offense on 4.3 yards per play. We’ll lay the points thinking Buffalo limits self-inflicted wounds while getting enough defensive stops.

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