The human brain which is one of the organs of the central nervous system which uses most of the energy of the human the body, energy sources such as glucose and ATP uses most of the energy other than the muscles.
And at the same point the strenuous mental process runs out of ATP. This does not affect muscles and other organs as they have their own energy depot.
However the brain notices the lack of energy, this is manifested by distraction, inability to concentrate and temporary deterioration of memory.
This condition can be corrected by a full meal and a healthy sleep after which the brain regain its lost energy and is ready to get to work again.
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